Ectopic Tbx2 expression results in polyploidy and cisplatin resistance

Is more better? Polyploidy and parasite resistance.

Ploidy-level variation is common and can drastically affect organismal fitness. We focus on the potential consequences of this variation for parasite resistance. First, we elucidate connections between ploidy variation and key factors determining resistance, including allelic diversity, gene expression and physiological condition. We then argue that systems featuring both natural and artificial...

Expression and clinical significance of tbx2 in pancreatic cancer.

TBX2 is one of the family of genes encoding developmental transcription factors, characterized by a 200 amino acid DNA binding domain (T-box), found to be related to malignant phenotypes of mammary cancer. However, the role of TBX2 in pancreatic cancer progression remains unclear. Therefore, the present study was conducted to investigate the expression and clinical significance of TBX2 in pancr...

Ectopic expression of RESISTANCE TO POWDERY MILDEW8.1 confers resistance to fungal and oomycete pathogens in Arabidopsis.

Broad-spectrum disease resistance is a highly valuable trait in plant breeding and attracts special attention in research. The Arabidopsis gene locus RESISTANCE TO POWDERY MILDEW 8 (RPW8) contains two adjacent homologous genes, RPW8.1 and RPW8.2, and confers broad-spectrum resistance to powdery mildew. Remarkably, the RPW8.2 protein is specifically localized to the extrahaustorial membrane (EHM...

TBX2 over-expression promotes nasopharyngeal cancer cell proliferation and invasion

TBX2 is a member of the T box transcription factor family. Its expression and potential biological functions in nasopharyngeal cancer (NPC) cells are studied here. We showed that TBX2 mRNA and protein expression was significantly elevated in multiple human NPC tissues, as compared with that in adjacent normal tissues. Knockdown of TBX2 by targeted-siRNA significantly inhibited proliferation and...

Ectopic expression in Drosophila.